Prof. Dr. Guido Beldi
Group Leader
Release of bacterial ATP in sepsis
Sepsis causes millions of deaths worldwide each year and is a current global health priority declared by the WHO. Sepsis related deaths are a result of dysregulated inflammatory immune responses with ATP a now known important mediator. ATP is released by inflamed host cells and also by bacteria in a strain-specific manner. We are investigating how bacteria ATP is released and its local and remote role in the pathogenesis of sepsis.
Understanding the origin of surgical site infections
We are investigating the impact of intestinal microbiota composition on bacterial translocation and infectious complications in the surgical setting. Our data highlights the importance of endogenous intestinal bacteria as a source for postoperative infection.
Machine learning interrogation of data to inform health care decisions
Predict postsurgical infections by integrating electronic health records with machine learning.
- The role of released bacterial ATP in shaping inflammatory immune responses during abdominal sepsis.
- Study the impact of intestinal microbiota composition on bacterial translocation and infectious complications in the surgical setting.
- Investigate the dynamics of peritoneal macrophages in regulating systemic wound healing.
- Detect postsurgical infections by integrating electronic health records with machine learning.
ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery. Jakob MO, et al. Cell Rep. 2023. PMID: 36933213
Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Dosch M, et al. Elife. 2019. PMID: 30735126
Modelling strategies to organize healthcare workforce during pandemics: Application to COVID-19. Sánchez-Taltavull, et al. J Theor Biol. 2021. PMID: 33862091
